Gastroscopy in Achlorhydria

Achlorhydria by ezrin knockdown

Loss of gastric acid secretion is pathologically known as achlorhydria. Acid-secreting parietal cells are characterized by abundant expression of ezrin (Vil2), one of ezrin/radixin/moesin proteins, which generally cross-link actin filaments with plasma membrane proteins. Here, we show the direct in vivo involvement of ezrin in gastric acid secretion. Ezrin knockout (Vil2(-/-)) mice did not surv...

Achlorhydria and Anæmia

Constitutive achlorhydria in mucolipidosis type IV.

Mucolipidosis type IV is an autosomal recessive lysosomal storage disease of unknown etiology that causes severe neurological and ophthalmological abnormalities. In an attempt to obtain insight into the nature of the metabolic abnormality in this disorder, we prospectively evaluated 15 consecutive patients, aged 2 to 23 years, over a period of 22 months. The finding of iron deficiency in some o...

Gastroscopy: A Survey

Gastroscopy is the latest endoscopic method to become established by achieving safety combined with useful vision, and yet it was one of the earliest attempted. In 1868, only five years after Desormeux had invented a method of illuminating an endoscope, Kussmaul1 published in Freiburg his attempt to examine the stomach of a professional sword swallower. His method was to pass a long straight me...

Achlorhydria: hypergastrinaemia: carcinoids--a flawed hypothesis?